PharmaceuticalsInventory policy and supply continuity

Raw-material buffers sized to usable stock

A material can be on site and still be unavailable to manufacturing. For a pharmaceutical manufacturer, Opyflow designed a planning model and policy that work from the supplier lead time, testing, release and shelf life of each of 200 raw materials.

Situation

To run commercial production, the company needed dependable access to its materials. Sourcing risk varied from item to item, and so did testing requirements and usable shelf life.

Opyflow's role

Opyflow built a safety-stock and lead-time model at the level of each material, with a planning database behind it. A written policy assigns ownership and sets the review and replenishment rules.

Documented outcomePlan or design

Buffer rules set for 200 raw materials · Testing and release built into replenishment timing · Review ownership and exception rules defined

The challenge

Materials followed different paths into production. Some needed laboratory release or extra preparation after receipt; others had short remaining shelf lives or long, uncertain replenishment times. For these, buying more could add to expiry exposure and still leave in place whatever kept the material unavailable.

Stock held for expected consumption had to be planned apart from stock held against disruption.

Opyflow's work

Each material was modelled on its own terms: how long and how reliably its supplier delivered, what testing and release it needed, any additional processing, how long it kept, and whether an alternative source existed. The model holds a quantity buffer and a separate timing buffer, so replenishment settles how much to hold and also how early the material has to arrive.

Production materials, consumables and laboratory supplies were each handled differently. Where shelf life was short, it put a ceiling on the proposed stock level. Materials with long qualification or release requirements needed their buffers held in a different position and status.

Under the policy, planners have defined responsibilities and replenishment checks for the decisions they make each week, adjustments go to management for review, and periodic updates are required. The policy also makes recommendations on inventory accuracy, expiry monitoring and who owns the material database.

Assess materialand supply risksSet quantity andtiming buffersCheck shelf lifeand releaseDefine replenishmentand review
Illustrative explanation of the work; not a client deliverable.

What changed

Proposed stock levels and replenishment timing, previously set by habit or a single rule, can now be traced to each item's supply and release conditions. The policy names who reviews the parameters and who approves exceptions.

Why include release time in the inventory policy?

Until its test result and release decision come through, delivered material cannot be used in production. Replenishment timing has to allow for that wait, and the stock held still has to fit within the material's usable shelf life.

See the capability: Inventory optimisation and safety-stock design →

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About Opyflow

Opyflow is an operations and supply chain consultancy, founded in 2019, working with manufacturers in regulated and high-complexity industries. Offices in Kiryat Ono, Israel and Melbourne, Australia; projects across Israel, Europe, the US and India. The senior person you talk to is the one who does the work.

We are done when it's in the P&L.

Release testing and shelf life decide how much of the stock you hold your production plan can actually use, and every site sets its buffers differently.